棉花生物学国家重点实验室

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研究队伍

师冰洋

1、个人简历
    师冰洋,男,1983年生,生物医学博士。河南大学特聘教授,博士生导师,“千人计划”青年学者,国家重点研发计划青年项目首席,兼任Frontier in Chemistry(IF 3.994)副编辑,Journal of Nanomaterials(IF 1.8)杂志客座主编。主要从事重大疾病的高精度检测和精准治疗研究,涉及早期检测和协同治疗(细胞治疗、药物治疗和基因治疗)等领域,已取得系统研究成果。近五年来,在稀土纳米晶的生物应用(Nature Nanotechnology 2015)、脑靶向药物传输(Small 2017, Nanoscale 2017)和药物可控释放(Advanced Materials 2013,Small 2014, Biomaterials 2014, Nano Letters 2017)等领域的主流期刊发表 SCI 论文 30 余篇。受邀为Trends in Biotechnology,Light 和Biomacromolecules 撰写脑靶向药物递送和脑疾病治疗的综述。曾联合澳洲和德国知名抗体公司研发出新一代稀土纳米晶(Nature Nanotechnology 2015),成功开发高精度早期疾病检测试剂盒,已进入了临床一期。

2、教育经历
2010-2013  澳大利亚阿德莱德大学  化学工程学院  博士
2006-2009  华东理工大学          生物工程学院  硕士
2002-2006  河南大学              生命科学学院  学士

3、工作经历
2016-至今 河南大学棉花生物学国家重点实验室 植物逆境生物学重点实验室 生命科学学院 教授
2015-2016 澳大利亚麦考瑞大学医学与健康科学学院 课题组组长 高级讲师(副教授)
2014-2015 澳大利亚麦考瑞大学医学与健康科学学院 独立研究员 课题组组长
2013-2014 澳大利亚麦考瑞大学医学与健康科学学院 博士后     研究员

4、承担项目
(1)澳大利亚独立研究员基金,2015-2017
(2)澳洲健康与卫生部老年痴呆症发展研究基金(APP1111611)
(3)国家重点研发计划青年项目(2018YFA0209800),2018-2023,275万
(4)中组部千人计划青年项目,2017-2019,200万
(5)国家自然科学基金青年项目,2019-2021,27万
(6)国家自然科学基金联合项目(U1604177),2017-2019,46万
(7)国家自然科学基金应急项目(31640027),2017-2017,15万

5、代表论文与著作
(1)Y. Zou#, Y. Liu #, Z. Yang, D. Zhang, Y. Lu, M. Zheng*, X. Xue, J. Geng, R. Chung, B. Shi*. Effective and Targeted Human Orthotopic Glioblastoma Xenografts Therapy via a Multifunctional Biomimetic Nanomedicine. Advanced Materials. DOI: 10.1002/adma.201803717R1
(2)Huijie Qi, Lihong Niu, Jie Zhang, Jian Chen, Shujie Wang, Jingjing Yang, Siyi Guo, Tom Lawson, Shi, B.Y.* & Chunpeng Song*. Large-area gold nanohole arrays fabricated by one-step method for surface plasmon resonance biochemical sensing. Science China-Life Sciences. 2018; 61: 476-482.
(3)Weimin Ruan, Meng Zheng*, Yang An, Yuanyuan Liu, David B. Lovejoy, Mingcong Hao, Yan Zou, Albert Lee, Shu Yang, Yiqing Lu, Marco Morsch, Roger Chung and Shi, B.Y.* DNA nanoclew templated spherical nucleic acid for siRNA delivery. Chemical Communications. 2018; 54: 3609-3612.
(4)Meng Zheng, Wei Tao, Yan Zou, Omid C. Farokhzad, and Shi, B.Y.* Nanotechnology based strategies for siRNA brain delivery for disease therapy. Trends in Biotechnology. 2018; 36: 562-575.
(5)Yi-Jung Ho, Yueh-Min Lin, Yen-Chi Huang, Shi, B.Y., Kun-Tu Yeh, Zhiyuan Gong. Prognostic significance of high YY1AP1 and PCNA expression in colon adenocarcinoma. Biochemical and Biophysical Research Communications. 2017; 494: 173-180.
(6)Albert Lee, Shi, B.Y., et al. Casein Kinase II Phosphorylation of cyclin F at Serine 621 regulates the Lys48-ubiquitylation E3 ligase activity of the SCF (cyclin F) complex. Open Biology. 2017; 7: 170058.
(7)Albert Lee, Shi, B.Y., et al Pathogenic mutation in the ALS/FTD gene, CCNF, causes elevated Lys48-linked ubiquitylation and defective autophagy. Cellular and Molecular Life Sciences. 2018; 75(2): 335-354.
(8)Ding, Li; Wang, Yilin; Zhu, Shi, B.Y., Xianbing; Ling, Xiang; Chen, Houjie; Nan, Wenhao; Austin, Barrett; Guo, Zilei; Tao, Wei; Wu, Jun*; Shi, Xiaojun*. Intracellular Fate of Nanoparticles with Polydopamine Surface Engineering and a Novel Strategy for Anti-Exocytosis Enhanced, Lysosome Impairment-Based Cancer Therapy. Nano Letter. 2017; 17 (11): 6790–6801.
(9)Fu, L., Morsch, M., Shi, B.Y.*, Lee, A., L, Jin, D., Chung, R. Versatile Upconvertion Surface Evaluation Platform for Bio-nano Surface Selection for Nervous System. Nanoscales, 2017; 9: 13683.
(10)Shi, B.Y.*, Zheng, M., Tao, W., Chung, R., Jin, D., Ghaffari, D., Farokhzad, O. Challenges in DNA Delivery and Recent Advances in Multifunctional Polymeric DNA Delivery System. Biomacromolecules.  2017; 18: 2231-2246.
(11)Shi, B.Y.*, Du, X., Chen, J., Fu, L., Morsch, M., Lee, A., Liu, Y., Cole, N., Chung, R. Multifunctional Hybrid Nanoparticles for Traceable Drug Delivery and Intracellular Microenvironment‐Controlled Multistage Drug‐Release in Neurons. Small. 2017; 3: 1603966.
(12)Zhou, M., Du, X., Li, W., Li, X., Huang, H., Liao, Q., Shi, B.Y., Zhang, X. One-pot synthesis of redox-triggered biodegradable hybrid nanocapsules with a disulfide-bridged silsesquioxane framework for promising drug delivery. J. Mater. Chem. B. 2017; 5: 4455-4469.
(13)Shimoni, O., Shi B.Y., Adlard, P., Bush, A. Delivery of fluorescent nanoparticles to the brain. Journal of Molecular Neuroscience. 2016; 60 (3): 405.
(14)Sayyadi N., Justiniano, I., Edwin C. R., Zhang R., Shi, B.Y., Kautto L., Everest-Dass, A., Yuan, J., Walsh, B., Jin, D., Willows, R., Piper, J., Packer, N.H. Sensitive time-gated immuno-luminescence detection of prostate cancer cells using a TEGylated europium ligand. Anal. Chem., 2016; 88 (19): 9564.
(15)Chen, J., He, M., Xu, P., Wu, H., Guo, Z., Shi, B.Y.*, Chen, Q. Photoluminescence distinction of lung adenocarcinoma cells A549 and squamous cells H520 using metallothionein expression in response to Cd-doped Mn 3 [Co (CN) 6] 2 nanocubes. RSC Adv. 2016; 6 (88): 84810.
(16)Zhou, B., Shi, B.Y., Jin, D.Y., Liu, X.G. Controlling upconversion nanocrystal for emerging applications. Nature Nanotechnology. 2015; 10: 924.
(17)Shi, B.Y., Jin, D. Rapid detection of rare-event cell by SUPER Dots based diagnostics nano-platform. J Controlled Release. 2015; 213: 11.
(18)Du, X., Shi, B.Y#. Liang, J, Bi, J.X., Dai, S. and Qiao, S.Z. Developing functionalized dendrimer-like silica nanoparticles with hierarchical pores as advanced delivery nanocarriers. Advanced Materials. 2013; 25: 5981.
(19)Rain, S., Shi, B.Y.*, Duss, A., Willow, R., Pipe J., Jin, D., Packer, N. Stable Upconversion Nanohybrid Particles for Specific Prostate Cancer Cell Immunodetection. Scientific Reports. 2016; 6: 37533.
(20)Shi, B.Y.,Zhang, H., Dai, S., Du, X., Bi, J.X. and Qiao, S.Z. Intracellular microenvironment responsive polymer: A multiple-stage transport platform for high-performance gene delivery. Small. 2014; 10(5): 871.
(21)Shi, B.Y., Zhang, H., Qiao, S.Z, Bi, J.X. and Dai, S. Intracellular Microenvironment Responsive Label-free Autofluorescent Nanogels for Traceable Gene Delivery. Advanced Healthcare Materials. 2014; 3 (11): 1839.
(22)Shi, B.Y., Shen, Z.Y, Zhang, H, Bi, J.X. and Dai, S. Exploring N-Imidazolyl-O-Carboxym-ethyl chitosan for high performance gene delivery. Biomacromolecules. 2012; 13: 146.
(23)Shi, B.Y,Zhang, H, Shen, Z.Y, Bi, J.X. and Dai, S. Developing a chitosan supported imidazole Schiff-base for high efficient gene delivery. Polymer Chemistry. 2013; 4: 840.
(24)Shi, B.Y., Zhang, H., Bi, J.X., Dai, S. Endosomal pH responsive polymers for efficient cancer targeted gene therapy. Colloids and Surfaces B: Biointerfaces. 2014; 119: 55.
(25)Deng, L, Shi, B.Y.*, Zhuang, Y.P, Shi, X.L, and Guo, M.J*, Performance and mechanism of neuroleukin in the growth and survival of embryonic neural stem cells in a co-culture system. Cell Transplantation. 2014; 23(3): 381.
(26)Cong, Y., Shi, B.Y. *, Lu, Y. Q., Wen, S. H., Chung, R., Jin, D.Y. One-step conjugation of glycyrrhetinic acid to cationic polymers for safe and efficient targeting gene delivery. Scientific Reports. 2016; 6: 21891.
(27)Shi, B.Y, Zhang, S.X, Wang, Y.H, Zhuang, Y.P, Chu, J. Shi, X.L, Bi, J.X. and Guo, M.J. Expansion of mouse sertoli cells on microcarriers. Cell Proliferation. 2010; 43: 275.
(28)Shi, B.Y., Zhang, M., Bi, J., Dai, S. Development of a novel folic acid chitosan supported imidazole Schiff base for tumor targeted gene delivery system and drug therapy. J Controlled Release. 2013; 1 (172): 98.
(29)Shi, B.Y.,Deng, L, Shi, X.L, Dai, S, Zhang, H, Wang, Y.H, Bi, J.X, and Guo, M.J, The enhancement of neural stem cell survival and growth by co-culturing with expanded sertoli cells in vitro. Biotechnology Progress. 2012; 28: 196.
(30)Du, X., Shi, B.Y., Tang, Y.H., Dai, S., Qiao, S.Z. Label-free dendrimer-like sillica nanohybrids for traceable and controlled gene delivery. Biomaterials. 2014; 35: 5580.
(31)Shi, B.Y.; Zhang S.X, Guo, M.J, Wang Y.H, Zhang, S.L, Shi X.L. Metabolic characterization of rat sertoli cell in vitro culture, Chin J Biotech. 2009; 25: 745.
(32)Cheng R., Ou Sheng., Bu Y., Li X., Liu X., Wang Y., Guo R., Shi, B.Y., Jin D. and Liu Y. Starch-borate-graphene oxide nanocomposites as highly efficient targeted antitumor drugs. RSC Adv. 2015; 5: 94855.
(33)Xiong, L., Du, X., Shi, B.Y., Bi, J., Kleitz, F., Qiao, S.Z. Tunable Stellate Mesoporous Silica Nanoparticles for Intracellular Drug Delivery. Journal of Materials Chemistry B. 2015; 3(8): 1712.
(34)Modra, K.E., Dai, S. Shi, B.Y., and Bi, J.X. Polycation-mediated gene delivery: challenges and considerations of processes for targeted therapies. Life science in engineering. 2015; 15: 489.
(35)Shen, Z.Y, Shi, B.Y, Zhang, H, Bi, J.X. and Dai, S. Exploring low-positively charged thermo sensitive copolymers as gene delivery vectors. Soft Matter. 2012; 8: 1385.
(36)Shen, Z.Y, Zhang, H, Shi, B.Y, Bi, J.X. and Dai, S. Exploring thermal reversible hydrogels for stem cell expansion in three-dimension. Soft Matter. 2012; 8: 7250.

6、联系方式
(1)邮箱:bs@henu.edu.cn
(2)通讯地址:河南省开封市河南大学金明校区